author-photo

Diederik Moechars

Janssen Pharmaceutica
Katholieke Universiteit Leuven

70

Papers

3318

Citations

Citation Trend

Filter By

Papers (43) Sort By

Journal Conference Others

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

2021 Journal of Medicinal Chemistry
Show All
- Source
- Cite
- Save
Citations (2)
Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions

2021 Journal of Medicinal Chemistry
Show All
- Source
- Cite
- Save
Citations (1)
Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer's disease.

2020 European Journal of Nuclear Medicine and Molecular Imaging
Show All
- Source
- Cite
- Save
Citations (5)
A family‐based genetic study identifies mutations in TLR9 impairing receptor activation: A role for innate immunity in AD pathogenesis: Developing topics

2020 Alzheimers & Dementia
Show All
- Source
- Cite
- Save
Citations (1)
Crystal Structure of BACE1 in complex with N-{3-[(4S)-2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-chloropyridine-2-carboxamide

2019
Show All
- Source
- Cite
- Save
Citations (0)
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

2019 Nature Neuroscience
Show All
- Source
- Cite
- Save
Citations (251)
Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2

2019 Journal of Medicinal Chemistry
Show All
- Source
- Cite
- Save
Citations (19)
BACE2 xaperone complex with N-{3-[(5R)-3-amino-5-methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide

2019
Show All
- Source
- Cite
- Save
Citations (0)
Crystal Structure of BACE1 in complex with N-{3-[(5R)-3-amino-5-methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide

2019
Show All
- Source
- Cite
- Save
Citations (0)
Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate

2018 Journal of Medicinal Chemistry
Show All
- Source
- Cite
- Save
Citations (13)