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Dieder Moechars

Janssen Pharmaceutica

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Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice.

2021 Neurobiology of Disease
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PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding.

2021 Journal of Biological Chemistry
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Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils

2021 Frontiers in Aging Neuroscience
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BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants

2017 Journal of Alzheimer's Disease
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Featured Article Profiling the dynamics of CSF and plasma Ab reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor

2016 Alzheimer's & Dementia: Translational Research & Clinical Interventions
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Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future

2015 Journal of Medicinal Chemistry
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Inositol-Related Gene Knockouts Mimic Lithium’s Effect on Mitochondrial Function

2014 Neuropsychopharmacology
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O-GlcNAc-ase inhibitor improves the clinical conditions of Alzheimer's disease mice

2013 Alzheimers & Dementia
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Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice

2013 PLOS ONE
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Inactivation of the Constitutively Active Ghrelin Receptor Attenuates Limbic Seizure Activity in Rodents

2012 Neurotherapeutics
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