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I-Wu Chen

United States Military Academy

33

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Metabolite identification of small interfering RNA duplex by high‐resolution accurate mass spectrometry

2008 Rapid Communications in Mass Spectrometry
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A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells

2005 Bioorganic & Medicinal Chemistry Letters
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A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

2004 Proceedings of the National Academy of Sciences of the United States of America
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Interaction with indinavir to enhance systemic exposure of an investigational HIV protease inhibitor in rats, dogs and monkeys

2003 Xenobiotica
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Pharmacokinetics and metabolism of a RAS farnesyl transferase inhibitor in rats and dogs: in vitro-in vivo correlation.

2001 Drug Metabolism and Disposition
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Oxo-piperazine Derivatives of N-Arylpiperazinones as Inhibitors of Farnesyltransferase

2001 Bioorganic & Medicinal Chemistry Letters
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ROUTE-DEPENDENT NONLINEAR PHARMACOKINETICS OF A NOVEL HIV PROTEASE INHIBITOR: INVOLVEMENT OF ENZYME INACTIVATION

2000 Drug Metabolism and Disposition
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Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.

2000 Bioorganic & Medicinal Chemistry Letters
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Comparison of imidazole- and 2-methyl imidazole-containing farnesyl-protein transferase inhibitors: interaction with and metabolism by rat hepatic cytochrome P450s.

2000 Drug Metabolism and Disposition
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Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

1998 Journal of Medicinal Chemistry
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Citations (84)