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Hong Ao

Johnson & Johnson Pharmaceutical Research and Development

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4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

2017 Journal of Medicinal Chemistry
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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.

2016 Bioorganic & Medicinal Chemistry Letters
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Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor

2016 Journal of Medicinal Chemistry
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Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists

2016 Bioorganic & Medicinal Chemistry Letters
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Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3-a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain

2016 ACS Chemical Neuroscience
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Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists

2015 ACS Medicinal Chemistry Letters
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Novel methyl substituted 1-(5,6-dihydro-(1,2,4)triazolo (4,3-a)pyrazin-7(8H)-yl)methanones are P2X7 antagonists

2015 Bioorganic & Medicinal Chemistry Letters
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Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists

2013 ACS Medicinal Chemistry Letters
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Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d] pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist

2011 European Journal of Pharmacology
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PHARMACOLOGICAL CHARACTERIZATION OF A PURINERGIC RECEPTOR (P2X7) ANTAGONIST IN-VITRO AND IN-VIVO

2010 The FASEB Journal
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