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Ben Davis

Ludwig Institute for Cancer Research

38

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Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.

2017 Journal of Medicinal Chemistry
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VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

2014 Oncotarget
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Abstract B155: VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and demonstrates context-dependent cytotoxicity to cancer cells.

2013 Molecular Cancer Therapeutics
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Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.

2012 Bioorganic & Medicinal Chemistry
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Structure-guided design of α-amino acid-derived Pin1 inhibitors

2010 Bioorganic & Medicinal Chemistry Letters
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Corrigendum to “Structure-guided design of α-amino acid-derived Pin1 inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 586]

2010 Bioorganic & Medicinal Chemistry Letters
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Abstract 4432: Discovery of novel Pin1 inhibitors by structure-guided fragment evolution that downregulate cyclin D1 expression in PC-3 prostate cancer cells

2010 Cancer Research
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Combining Hit Identification Strategies: Fragment- Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-D]Pyrimidine Inhibitors of the Hsp90 Molecular Chaperone.

2009 Journal of Medicinal Chemistry
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The SeeDs approach: integrating fragments into drug discovery.

2007 Current Topics in Medicinal Chemistry
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Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets

2004 Journal of Chemical Information and Computer Sciences
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