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Kathleen M. Ruppel

Stanford University

69

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1971

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Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state.

2021 Proceedings of the National Academy of Sciences of the United States of America
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Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

2021 bioRxiv
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Molecular Mechanisms and Cellular Models of Hypertrophic Cardiomyopathy: Insights from a Surprising Mutation

2021 Biophysical Journal
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Altered Cardiac Energetics and Mitochondrial Dysfunctionin Hypertrophic Cardiomyopathy

2021 Circulation
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The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

2020 Science Advances
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Hypertrophic cardiomyopathy ß-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state

2020 bioRxiv
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Abstract 235: Hypertrophic Cardiomyopathy, a Disease of Altered Cardiac Energetics

2020 Circulation Research
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The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches.

2020 Annual Review of Biochemistry
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Uncovering the Molecular and Structural Basis of Hypertrophic Cardiomyopathy-Causing Mutations in Myosin and Myosin Binding Protein-C

2020 Biophysical Journal
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Abstract 212: Hypertrophic Cardiomyopathy Mutations With Opposite Effects on ß-myosin Biomechanics Show Similar Structural and Biomechanical Phenotypes in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (hipsc-cms)

2019 Circulation Research
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