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Mingxin Qian

Bristol-Myers Squibb

22

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894

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A biocatalytic redox cascade approach for one-pot deracemization of carboxyl-substituted tetrahydroisoquinolines by stereoinversion

2019 Green Chemistry
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Role of Intestinal P-Glycoprotein in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents

2008 Drug Metabolism and Disposition
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N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.

2008 Journal of Pharmaceutical Sciences
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α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)

2008 Bioorganic & Medicinal Chemistry Letters
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Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors

2008 Bioorganic & Medicinal Chemistry Letters
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A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1′ group for the β-amino hydroxamic acid derived TACE inhibitors

2007 Bioorganic & Medicinal Chemistry Letters
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Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans

2007 Drug Metabolism and Disposition
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Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.

2004 Bioorganic & Medicinal Chemistry Letters
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The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: Model characterization and application

2004 Drug Metabolism and Disposition
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Sultam hydroxamates as novel matrix metalloproteinase inhibitors

2004 Journal of Medicinal Chemistry
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Citations (77)