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Patrick Y.S. Lam

Bristol-Myers Squibb

57

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Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability

2019 Bioorganic & Medicinal Chemistry Letters
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Potent, Orally Bioavailable and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.

2019 Journal of Medicinal Chemistry
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Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency

2017 Bioorganic & Medicinal Chemistry Letters
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Novel phenylalanine derived diamides as Factor XIa inhibitors.

2016 Bioorganic & Medicinal Chemistry Letters
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2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists.

2014 Bioorganic & Medicinal Chemistry Letters
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Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent

2014 Bioorganic & Medicinal Chemistry Letters
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Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties.

2014 Bioorganic & Medicinal Chemistry Letters
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Oral Delivery of Highly Lipophilic Poorly Water-Soluble Drugs: Spray-Dried Dispersions to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a P2Y1 Antagonist

2014 Journal of Pharmaceutical Sciences
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Differential effects of P2Y1 versus P2Y12 receptor antagonism on thrombosis and bleeding in rabbits

2013 European Heart Journal
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New azole antagonists with high affinity for the P2Y1 receptor

2013 Bioorganic & Medicinal Chemistry Letters
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Citations (18)