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Betsy S. Pierce

Pfizer

25

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707

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Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells

2017 ACS Chemical Biology
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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

2017 PLOS ONE
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Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

2017 Journal of Medicinal Chemistry
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Visible‐Light‐Driven Photocatalytic Initiation of Radical Thiol—Ene Reactions Using Bismuth Oxide.

2016 ChemInform
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Visible-Light-Driven Photocatalytic Initiation of Radical Thiol–Ene Reactions Using Bismuth Oxide

2015 Organic Letters
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Composés à base d'hétéroaryle ou d'aryle fusionné-bicyclique et leur utilisation comme composés inhibiteurs de l'irak 4

2015
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Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.

2012 Journal of Medicinal Chemistry
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A Benzothiophene Inhibitor of MAPK-Activated Protein Kinase 2 (MK2) Inhibits TNFα Production and has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation.

2010 Journal of Pharmacology and Experimental Therapeutics
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Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.

2010 Bioorganic & Medicinal Chemistry Letters
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Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist

2010 Bioorganic & Medicinal Chemistry Letters
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Citations (31)