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Jeanne S. Chang

Pfizer

17

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631

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Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

2017 Journal of Medicinal Chemistry
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Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.

2016 Angewandte Chemie
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Crystal structure of SYK kinase domain with N-(4-methyl-3-(8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide

2012
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PMP-bound form of Aminotransferase crystal structure from Vibrio fluvialis

2012
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Identification of Type-II Inhibitors Using Kinase Structures.

2012 Chemical Biology & Drug Design
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PLP-bound aminotransferase mutant crystal structure from Vibrio fluvialis

2012
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Structure of the adenylation domain of NAD+-dependent DNA ligase from Staphylococcus aureus

2009 Acta Crystallographica Section F-structural Biology and Crystallization Communications
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Crystal Structure of the Herpes Simplex Virus 1 DNA Polymerase

2006 Journal of Biological Chemistry
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Citations (138)