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Kelly Hamilton

Merck & Co.

13

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siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds

2014 Pharmaceutical Research
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Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.

2008 Journal of Medicinal Chemistry
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Biochemical Characterization of a Class of Inhibitors of the Human Mitotic Kinesin KSP with a Novel Mechanism of Action

2006 The FASEB Journal
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Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl: protein transferase and geranylgeranyl:protein transferase type-I

2002 Molecular Cancer Therapeutics
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N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.

1999 Journal of Medicinal Chemistry
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Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase.

1999 Journal of Medicinal Chemistry
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A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

1998 Molecular and Cellular Biology
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Selection of Potent Inhibitors of Farnesyl-protein Transferase from a Synthetic Tetrapeptide Combinatorial Library

1996 Journal of Biological Chemistry
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2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.

1996 Journal of Medicinal Chemistry
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Citations (47)