siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds

Rob Burke,Inthirai Somasuntharam,Paul Rearden,Duncan Brown,Sujal V. Deshmukh,Martha A. DiPietro,Jillian DiMuzio,Roy Eisenhandler,Scott E. Fauty,Christopher Gibson,Marian Gindy,Kelly Hamilton,Ian Knemeyer,Kenneth A. Koeplinger,Hae Won Kwon,Traci Q. Lifsted,Karsten Menzel,Mihir Patel,Nicole T. Pudvah,Deanne Rudd,Jessica Seitzer,Walter Strapps,Thomayant Prueksaritanont,Charles D. Thompson,Jerome H. Hochman,Brian A. Carr

siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds

2014

Purpose To develop a tool based on siRNA-mediated knockdown of hepatic P450 oxidoreductase (POR) to decrease the CYP-mediated metabolism of small molecule drugs that suffer from rapid metabolism in vivo, with the aim of improving plasma exposure of these drugs.

Keywords:

Gene knockdown
Small molecule
Metabolism
Oxidoreductase
In vivo
Biology
Molecular biology
Biochemistry
plasma exposure
p450 oxidoreductase
Chemistry
pharmacology toxicology
Pharmacology

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