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Hans E. Parge

Scripps Research Institute

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Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

2009 Journal of Medicinal Chemistry
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Structure-based design of novel human Pin1 inhibitors (I).

2009 Bioorganic & Medicinal Chemistry Letters
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Structure-Based Design of Novel PIN1 Inhibitors (I)

2009 Bioorganic & Medicinal Chemistry Letters
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In Vitro Resistance Study of AG-021541, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

2008 Antimicrobial Agents and Chemotherapy
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Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.

2006 Bioorganic & Medicinal Chemistry Letters
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Crystal structure of the RNA-dependent RNA polymerase 3D from human rhinovirus serotype 14

2004
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Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor.

2004
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The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy.

2004 Structure
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Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

2003 Journal of Virology
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Hepatitis C Virus (HCV) NS5B RNA Polymerase und davon abgeleitete Mutanten

2002
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