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Tom T. Lee

University of California, San Francisco

16

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366

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E. coli thymidylate synthase mutant I264Am

2018
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A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer.

2018 Biochemistry
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Thymidylate synthase ternary complex with dUMP AND CB3717

2013
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E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog

2012
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Structure of a TrmA–RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases

2008 Proceedings of the National Academy of Sciences of the United States of America
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High resolution structure of Escherichia coli thymidylate synthase ternary complex with dUMP and a cofactor analog, CB3717

2006
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The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261

2006 Biochemistry
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Escherichia coli Y209W apoprotein

2006
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Crystal Structure of E. coli 5-methyluridine methyltransferase RumA in complex with ribosomal RNA substrate and S-adenosylhomocysteine.

2005
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Effects of Subunit Occupancy on Partitioning of an Intermediate in Thymidylate Synthase Mutants

2000 Biochemistry
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