Thymidylate synthase

1YPV, 1JU6, 2RDA, 3EF9, 3ED7, 1HW3, 3EHI, 3GH0, 4JEF, 4O1X, 1HZW, 3EAW, 3OB7, 3EBU, 4KPW, 3EGY, 3EJL, 3N5G, 3N5E, 1HVY, 4GD7, 4G2O, 4H1I, 2ONB, 3H9K, 4GYH, 3HB8, 1I00, 3GG5, 4FGT, 2RD8, 3EDW, 4G6W, 1HW4, 3GH2, 4E28, 1JUJ, 4O1U, 4UP1, 5HS3,%%s1HW3, 1YPV, 4GD7, 2ONB729822171ENSG00000176890ENSMUSG00000025747P04818Q53Y97P07607NM_001071NM_001354867NM_001354868NM_021288NP_001062NP_001341796NP_001341797NP_001062.1NP_067263Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage.1hvy: Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation1hw3: STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS1hw4: STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS1hzw: CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE1i00: CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE, TERNARY COMPLEX WITH DUMP AND TOMUDEX1ju6: Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate1juj: Human Thymidylate Synthase Bound to dUMP and LY231514, a Pyrrolo(2,3-d)pyrimidine-based Antifolate1ypv: Structure of human thymidylate synthase at low salt conditions2onb: Human Thymidylate Synthase at low salt conditions with PDPA bound Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage.