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Alan Hruza

Schering-Plough

34

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COMPOSÉS UTILES POUR MODIFIER LES TAUX D'ACIDES BILIAIRES POUR LE TRAITEMENT DU DIABÈTE ET DE MALADIES CARDIOMÉTABOLIQUES.

2018
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Structure of the insulin receptor in complex with insulin using single-particle cryo-EM analysis

2018 Acta Crystallographica Section A
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Structure-based drug design of clinical compound MK-8353, a novel inhibitor of ERK

2018 Acta Crystallographica Section A
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Structure of the Insulin Receptor in Complex with Insulin using Single Particle CryoEM Analysis

2017 Microscopy and Microanalysis
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Discovery of novel chiral 3o-SMe pyrrolidine as extracellular regulated kinase (ERK) inhibitors

2016
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Dissecting Therapeutic Resistance to ERK Inhibition Rat Wild Type SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide

2016
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The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia

2012 Bioorganic & Medicinal Chemistry Letters
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Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia

2011
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Abstract 2785: Modulating the interaction between cdk2 and cyclin A: Screening, synthesis and characterization of a quinoline-based inhibitor

2011 Cancer Research
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Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core

2010 ACS Medicinal Chemistry Letters
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