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Wen-Lian Wu

Merck & Co.

35

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275

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Abstract 1145: AGX323 - A SAM-competitive, orally available inhibitor of protein arginine methyltransferase 5 (PRMT5) with potent cellular antiproliferative and in vivo antitumor activity against selected solid cancer types

2021 Cancer Research
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Design and Discovery of C2-fluoroalkyl Iminothiazine Dioxides as BACE Inhibitors.

2021 Bioorganic & Medicinal Chemistry Letters
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Abstract C082: AGX-73, a novel small molecule multi-immunokinase inhibitor, has robust antitumor activity in murine syngeneic tumor models as a single agent and in combination with anti-PD1 checkpoint inhibitor

2019 Molecular Cancer Therapeutics
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COMPOSÉS UTILES POUR MODIFIER LES TAUX D'ACIDES BILIAIRES POUR LE TRAITEMENT DU DIABÈTE ET DE MALADIES CARDIOMÉTABOLIQUES.

2018
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Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

2016 Bioorganic & Medicinal Chemistry Letters
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Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors.

2015 Journal of Medicinal Chemistry
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Iminothiazines 2-spiro-substituées et leur mono- et dioxydes en tant qu'inhibiteurs bace, compositions et leur utilisation

2012
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Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain

2012 Bioorganic & Medicinal Chemistry Letters
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Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

2012 ACS Medicinal Chemistry Letters
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Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

2010 Bioorganic & Medicinal Chemistry Letters
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