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James E. Brownell

Millennium Pharmaceuticals

10

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Absolute Quantification of E1, Ubiquitin-Like Proteins and Nedd8–MLN4924 Adduct by Mass Spectrometry

2013 Cell Biochemistry and Biophysics
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Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924

2012 Cancer Cell
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Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

2011 Nature Reviews Drug Discovery
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Abstract C28: Treatment emergent mutations in NAEbeta confer resistance to the investigational NEDD8-activating enzyme inhibitor MLN4924.

2011 Molecular Cancer Therapeutics
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Treatment Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML and DLBCL Models

2011 Blood
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Abstract C82: Identification and preclinical characterization of inhibitors of the ubiquitin-activating enzymes UBA1 and UBA6.

2011 Molecular Cancer Therapeutics
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The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.

2010 Genes & Cancer
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Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.

2010 Molecular Cell
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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

2009 Nature
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