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Mark Manfredi

Millennium Pharmaceuticals
Takeda Pharmaceutical Company

88

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2462

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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.

2021 Nature Communications
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Abstract PR05: Blockade of AHR activation by IDO/TDO-derived kynurenine restricts cancer immune suppression

2020 Cancer immunology research
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Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

2020 Nature Communications
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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.

2020 Cancer Discovery
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Abstract B008: Treatment of IDO1 and TDO2 positive tumors with a kynurenine-degrading enzyme: A highly differentiated approach from IDO1 inhibition

2019 Cancer immunology research
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Abstract 4131: Overcoming aryl hydrocarbon receptor mediated tumor immunosuppression

2019 Immunology
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A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo

2018 PLOS ONE
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Abstract 4723: Targeting the IDO and TDO pathway through inhibition of the aryl hydrocarbon receptor

2018 Cancer Research
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Abstract 5571: Immune-checkpoint inhibition via enzyme-mediated degradation of kynurenine

2017 Cancer Research
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Crystal structure of homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), in complex with glycine, PLP and folate-competitive pyrazolopyran inhibitor: 6-amino-4-isopropyl-3-methyl-4-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

2017
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