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Julie Zhang

Millennium Pharmaceuticals

14

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1589

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A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo

2018 PLOS ONE
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329 The Investigational Drug MLN0264 First-in-human, First in Class ADC Targeting GCC: Phase I Dose-escalation Study and Supportive Scientific Rationale

2012 European Journal of Cancer
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MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

2010 Blood
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Abstract B40: Development of a pharmacodynamic assay for the second‐generation proteasome inhibitor MLN9708 in clinical trials of multiple myeloma

2009 Molecular Cancer Therapeutics
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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

2009 Nature
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Abstract B34: Clinical pharmacodynamic assay development for the first small molecule inhibitor of Nedd8‐activating enzyme (NAE), MLN4924

2009 Molecular Cancer Therapeutics
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85 POSTER Pharmacodynamic and efficacy relationship of MLN4924, a novel small molecule inhibitor of Nedd8-activating enzyme, in human xenograft tumors grown in immunocompromised mice

2008 Ejc Supplements
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Preclinical evaluation of MLN4924, the first small molecule inhibitor of NEDD8-activating enzyme (NAE) for the treatment of cancer

2007 Molecular Cancer Therapeutics
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