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Luc Tritsmans

Janssen Pharmaceutica

27

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339

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Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial

2021 Journal of Medicinal Chemistry
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Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer’s disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study

2020 Alzheimer's Research & Therapy
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Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease

2019 Neurobiology of Aging
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Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer’s disease: randomized, double-blind, placebo-controlled study

2018 Alzheimer's Research & Therapy
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Evaluating Potential QT Effects of JNJ‐54861911, a BACE Inhibitor in Single‐ and Multiple‐Ascending Dose Studies, and a Thorough QT Trial With Additional Retrospective Confirmation, Using Concentration‐QTc Analysis

2018 The Journal of Clinical Pharmacology
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BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants

2017 Journal of Alzheimer's Disease
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PHARMACOKINETIC/PHARMACODYNAMIC MODELING OF CSF AB1-40 REDUCTION IN AN EARLY ALZHEIMER'S DISEASE STUDY OF JNJ-54861911, AN ORAL BACE1 INHIBITOR

2016 Alzheimers & Dementia
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PHARMACODYNAMICS OF THE ORAL BACE INHIBITOR JNJ-54861911 IN EARLY ALZHEIMER'S DISEASE

2016 Alzheimers & Dementia
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PHARMACOCOKINETIC AND PHARMACODYNAMIC STUDY (54861911ALZ1006) WITH A BACE INHIBITOR, JNJ-54861911, IN HEALTHY ELDERLY JAPANESE SUBJECTS

2016 Alzheimers & Dementia
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Featured Article Profiling the dynamics of CSF and plasma Ab reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor

2016 Alzheimer's & Dementia: Translational Research & Clinical Interventions
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