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Mira Patel

22

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377

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Small-Molecule Approaches for the Treatment of Sickle Cell Disease

2019
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Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease

2019 British Journal of Clinical Pharmacology
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Decreased behavioural and neurochemical effects of angiotensin IV following prenatal alcohol exposure in the mouse

2019 Neuropeptides
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GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions

2018 Clinical Hemorheology and Microcirculation
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GBT1118 Diminishes Vaso-Occlusion in Sickle Cell Disease Mice

2017 Blood
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Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

2017 ACS Medicinal Chemistry Letters
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Increased hemoglobin-oxygen affinity ameliorates bleomycin-induced hypoxemia and pulmonary fibrosis.

2016 Physiological Reports
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Long-Term Dosing in Sickle Cell Disease Subjects with GBT440, a Novel HbS Polymerization Inhibitor

2016 Blood
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GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

2015 Blood
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GTx011, an Anti-Sickling Compound, Improves SS Blood Rheology By Reduction of HbS polymerization Via Allosteric Modulation of O2 Affinity

2014 Blood
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