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Larysa N. Patskovska

Albert Einstein College of Medicine

14

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Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

2017 ACS Medicinal Chemistry Letters
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CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT440, CO-CRYSTALLIZATION EXPERIMENT

2016
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Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a.

2006 Biochemistry
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COHbC and COHbS crystallize in the R2 quaternary state at neutral pH in the presence of PEG 4000.

2005 Acta Crystallographica Section D-biological Crystallography
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Structure of mutant human carbonmonoxyhemoglobin C (βE6K) at 2.0 Å resolution

2002 Acta Crystallographica Section D-biological Crystallography
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Structure of mutant human carbonmonoxyhemoglobin C (βE6K) at 2.0 Å resolution

2002 Acta Crystallographica Section D-biological Crystallography
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The Enhanced Affinity for Thiolate Anion and Activation of Enzyme-bound Glutathione Is Governed by an Arginine Residue of Human Mu Class Glutathione S-Transferases

2000 Journal of Biological Chemistry
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An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases.

1999 Biochemistry
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Functions of His107 in the catalytic mechanism of human glutathione S-transferase hGSTM1a-1a.

1999 Biochemistry
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Expression, crystallization and preliminary X-ray analysis of ligand-free human glutathione S-transferase M2–2

1998 Acta Crystallographica Section D-biological Crystallography
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Citations (7)