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Masayuki Mishima

Chugai Pharmaceutical Co.

26

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189

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Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS.

2021
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In vitro toxicological support to establish specification limit for anti-CD3 monospecific impurity in a bispecific T cell engager drug, ERY974.

2020 Toxicology in Vitro
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High-content imaging analyses of γH2AX-foci and micronuclei in TK6 cells elucidated genotoxicity of chemicals and their clastogenic/aneugenic mode of action

2019 Genes and Environment
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In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity

2019 Journal of Immunotoxicology
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In Vitro Mammalian Cell Mutation Assays Based On Transgenic Reporters: a Report of the International Workshop on Genotoxicity Testing (IWGT)

2019 Mutation Research-genetic Toxicology and Environmental Mutagenesis
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Advantages of evaluating γH2AX induction in non-clinical drug development

2018 Genes and Environment
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Different players generate positive responses in two in vitro cytokine assay formats with aqueous and immobilized TGN1412 analog

2018 Biochemical and Biophysical Research Communications
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Derivation of acceptable daily exposure value for alanine, N,N -bis(carboxymethyl)-, trisodium salt

2018 Fundamental Toxicological Sciences
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Meeting report, ICH M7 relevant workshop: use of (Q)SAR systems and expert judgment

2018 Genes and Environment
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Giemsa-stained pseudo-micronuclei in rat skin treated with vitamin D 3 analog, pefcalcitol

2017 Genes and Environment
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