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Ted Judd

Amgen

20

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306

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Identification and Development of AMG 986: A Potent and Efficacious APJ Agonist for the Treatment of Heart Failure

2020
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Access to substituted trifluoromethyl ketones using the versatile synthetic intermediate (E)-1,1-dimethyl-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine

2017 Tetrahedron Letters
- Ted Judd
- Derek B. Brown
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Correction to Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

2017 Journal of Medicinal Chemistry
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Agonists triazole apj receptor

2016
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Crystal structure of BACE1 in complex with 3-(2-amino-6-(o-tolyl)quinolin-3-yl)-N-(3,3-dimethylbutyl)propanamide

2016
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Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.

2015 Bioorganic & Medicinal Chemistry Letters
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An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities

2015 ACS Medicinal Chemistry Letters
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Composés perfluorés 5,6-dihydro-4h-1,3-oxazine-2-amine substitués en tant qu'inhibiteurs de la bêta-sécrétase et procédés d'utilisation correspondants

2014
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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.

2012 ACS Medicinal Chemistry Letters
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Pharmacokinetic and pharmacodynamic evaluation of orally available hydroxyethylamine-derived beta-secretase inhibitors in Sprague Dawley rats

2012 Alzheimers & Dementia
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