Access to substituted trifluoromethyl ketones using the versatile synthetic intermediate (E)-1,1-dimethyl-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine
2017
Abstract The N,N -dimethylhydrazone of 1,1,1-trifluoroacetone, ( E )-1,1-dimethyl-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine, has been shown to undergo a diverse set of reactions following deprotonation with n- butyl-lithium; including alkylation, addition to ketones and aldehydes, as well as palladium-catalyzed cross-couplings with aryl bromides. Mild hydrolysis of the N,N -dimethylhydrazone products from these transformations affords the corresponding trifluoromethyl ketones in good to excellent yields.
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