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Xiaofeng Gu

University of California, Los Angeles

15

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1102

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A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles.

2017 Human Molecular Genetics
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Serine 421 regulates mutant huntingtin toxicity and clearance in mice

2016 Journal of Clinical Investigation
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N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice

2015 Neuron
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Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease

2014 Nature Medicine
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Cellular and molecular mechanisms implicated in pathogenesis of selective neurodegeneration in Huntington’s disease

2012 Frontiers of Biology in China
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Faculty Opinions recommendation of Optineurin in Huntington's disease intranuclear inclusions.

2012
- X. William Yang
- Xiaofeng Gu
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An Antisense CAG Repeat Transcript at JPH3 Locus Mediates Expanded Polyglutamine Protein Toxicity in Huntington's Disease-like 2 Mice

2011 Neuron
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Faculty Opinions recommendation of Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.

2010
- X. William Yang
- Xiaofeng Gu
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Serines 13 and 16 Are Critical Determinants of Full-length Human Mutant Huntingtin-Induced Disease Pathogenesis in HD Mice

2009 Neuron
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Faculty Opinions recommendation of Towards a transgenic model of Huntington's disease in a non-human primate.

2008
- X. William Yang
- Xiaofeng Gu
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