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Joan S. Steffan

University of California, Irvine

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PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.

2021 Proceedings of the National Academy of Sciences of the United States of America
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Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease.

2021
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Decision letter: Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

2021 eLife
- Joan S. Steffan
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Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models

2021 International Journal of Molecular Sciences
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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.

2020 Nature Communications
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Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila.

2020 Experimental Neurology
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IKKβ slows Huntington’s disease progression in R6/1 mice

2019 Proceedings of the National Academy of Sciences of the United States of America
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Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice

2018 Journal of Huntington's disease
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Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice

2018 Stem cell reports
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Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies.

2017 Stem Cells Translational Medicine
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