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Appleby Sd
Appleby Sd
Biochemistry
Thrombin
Discovery and development of direct thrombin inhibitors
Bioavailability
Enzyme inhibitor
4
Papers
177
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Lack of beneficial effects of growth hormone treatment in conscious dogs during development of heart failure
1998
American Journal of Physiology-heart and Circulatory Physiology
You-Tang Shen
R. F. Woltmann
Appleby Sd
S. Prahalada
Stephen Krause
S. D. Kivilghn
R. G. Johnson
P K Siegl
Joseph J. Lynch
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Citations (25)
Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460) : Coapplication of structure-based design and rapid multiple analogue synthesis on solid support
1998
Journal of Medicinal Chemistry
Stephen F. Brady
Kenneth J. Stauffer
William C. Lumma
Smith Gm
Ramjit Hg
Lewis Sd
Lucas Bj
Stephen J. Gardell
Elizabeth A. Lyle
Appleby Sd
Jacquelynn J. Cook
Marie A. Holahan
Maria T. Stranieri
Joseph J. Lynch
Jiunn H. Lin
I-Wu Chen
Kari Vastag
Adel M. Naylor-Olsen
Vacca Jp
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Citations (69)
Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position
1997
Journal of Medicinal Chemistry
Thomas J. Tucker
William C. Lumma
Lewis Sd
Stephen J. Gardell
Lucas Bj
John T. Sisko
Joseph J. Lynch
Elizabeth A. Lyle
Elizabeth P. Baskin
Woltmann R
Appleby Sd
I-Wu Chen
Dancheck Kb
Adel M. Naylor-Olsen
Julie A. Krueger
Carolyn M. Cooper
Vacca Jp
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Citations (28)
Potent Noncovalent Thrombin Inhibitors That Utilize the Unique Amino Acid d-Dicyclohexylalanine in the P3 Position. Implications on Oral Bioavailability and Antithrombotic Efficacy
1997
Journal of Medicinal Chemistry
Thomas J. Tucker
William C. Lumma
Lewis Sd
Stephen J. Gardell
Lucas Bj
Elizabeth P. Baskin
Woltmann R
Joseph J. Lynch
Elizabeth A. Lyle
Appleby Sd
I-Wu Chen
Dancheck Kb
Joseph P. Vacca
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Citations (55)
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