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Kathleen Aertgeerts

Takeda Pharmaceutical Company

9

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646

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High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.

2014 Nature
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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.

2012 Bioorganic & Medicinal Chemistry
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Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.

2011 Bioorganic & Medicinal Chemistry
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Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

2011 Bioorganic & Medicinal Chemistry
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Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554

2011 Bioorganic & Medicinal Chemistry
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Corrigendum to “Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554” [Bioorg. Med. Chem. 19 (2011) 4482–4498]

2011 Bioorganic & Medicinal Chemistry
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Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein Alpha

2005 Journal of Biological Chemistry
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Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation

2004 Protein Science
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Citations (134)