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Miyuki Funami

Takeda Pharmaceutical Company

17

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668

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Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug-drug interactions in rat liver.

2017 Xenobiotica
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Design, synthesis, and structure–activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors

2012 Bioorganic & Medicinal Chemistry Letters
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Identification of Fused-Ring Alkanoic Acids with Improved Pharmacokinetic Profiles that Act as G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonists

2012 Journal of Medicinal Chemistry
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Discovery of Phenylpropanoic Acid Derivatives Containing Polar Functionalities as Potent and Orally Bioavailable G Protein-Coupled Receptor 40 Agonists for the Treatment of Type 2 Diabetes

2012 Journal of Medicinal Chemistry
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Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.

2012 Bioorganic & Medicinal Chemistry Letters
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A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: design and synthesis of benzylpyrazole acylsulfonamides.

2012 Bioorganic & Medicinal Chemistry
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Corrigendum to “Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors” [Bioorg. Med. Chem. Lett. 22 (2012) 4769–4772]

2012 Bioorganic & Medicinal Chemistry Letters
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Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent.

2012 Journal of Medicinal Chemistry
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Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists.

2012 Bioorganic & Medicinal Chemistry
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Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.

2011 Bioorganic & Medicinal Chemistry
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Citations (24)