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Garrick Smith
Garrick Smith
Novartis
Thrombin
Discovery and development of direct thrombin inhibitors
Biochemistry
Chemistry
Enzyme inhibitor
5
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61
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The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position
2000
Bioorganic & Medicinal Chemistry Letters
Urs Baettig
Lyndon Nigel Brown
Derek E. Brundish
Colin Dell
Alex Furzer
Sheila Garman
Diana Janus
Peter Kane
Garrick Smith
Clive Victor Walker
Xiaoling Cockcroft
John Ambler
Andrew Mitchelson
Mark Talbot
Morris Tweed
Nicholas Wills
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Citations (8)
Studies towards the identification of potent, selective and bioavailable thrombin inhibitors.
1999
Bioorganic & Medicinal Chemistry Letters
John Ambler
Emma Baker
Dave Bentley
Lyndon Nigel Brown
Keith Butler
Paul Butler
Dave Farr
Karen Dunnet
Darren Mark Le Grand
Judy Hayler
Diana Janus
Darryl Brynley Jones
Keith Menear
Mark Mercer
Garrick Smith
Mark Talbot
Morris Tweed
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Citations (7)
Optimisation of the P2 pharmacophore in a series of thrombin inhibitors: Ion-dipole interactions with lysine 60G
1999
Bioorganic & Medicinal Chemistry Letters
John Ambler
Lyndon Nigel Brown
Xiaoling Cockcroft
Markus G. Grütter
Judy Hayler
Diana Janus
Darryl Brynley Jones
Peter Kane
Keith Menear
John P. Priestle
Garrick Smith
Mark Talbot
Clive Victor Walker
Bernard Wathey
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Citations (5)
Design and synthesis of thrombin inhibitors: analogues of MD-805 with reduced stereogenicity and improved potency.
1999
Journal of Medicinal Chemistry
Derek E. Brundish
Bull A
Donovan
Joseph D. Fullerton
Sheila Garman
Judy Hayler
Diana Janus
Peter Kane
McDonnell M
Garrick Smith
Wakeford R
Clive Victor Walker
Graham Arton Howarth
William Hoyle
Mark C. Allen
John Ambler
Keith Butler
Talbot
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Citations (31)
The discovery of orally available thrombin inhibitors: studies towards the optimisation of CGH1668.
1998
Bioorganic & Medicinal Chemistry Letters
John Ambler
Emma Baker
Lyndon Nigel Brown
Paul Butler
Dave Farr
Karen Dunnet
Darren Mark Le Grand
Diana Janus
Darryl Brynley Jones
Keith Menear
Mark Mercer
Garrick Smith
Mark Talbot
Morris Tweed
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Citations (10)
1