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Yoshiyuki Tsujihata

Takeda Pharmaceutical Company

20

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838

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Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration.

2020 Cell
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SCO-267, a GPR40 full agonist, improves glycemic and body weight control in rat models of diabetes and obesity.

2019 Journal of Pharmacology and Experimental Therapeutics
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Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia

2017 EBioMedicine
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Fasiglifam/TAK-875, a Selective GPR40 Agonist, Improves Hyperglycemia in Rats Unresponsive to Sulfonylureas and Acts Additively with Sulfonylureas.

2016 Journal of Pharmacology and Experimental Therapeutics
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Fasiglifam (TAK‐875) has dual potentiating mechanisms via Gαq‐GPR40/FFAR1 signaling branches on glucose‐dependent insulin secretion

2016 Pharmacology Research & Perspectives
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Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists.

2014 Bioorganic & Medicinal Chemistry
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Identification of Fused-Ring Alkanoic Acids with Improved Pharmacokinetic Profiles that Act as G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonists

2012 Journal of Medicinal Chemistry
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Discovery of Phenylpropanoic Acid Derivatives Containing Polar Functionalities as Potent and Orally Bioavailable G Protein-Coupled Receptor 40 Agonists for the Treatment of Type 2 Diabetes

2012 Journal of Medicinal Chemistry
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Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent.

2012 Journal of Medicinal Chemistry
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TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.

2011 Journal of Pharmacology and Experimental Therapeutics
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Citations (123)