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Margaret E. McCann

Merck & Co.

13

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1114

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Benzimidazolones: A New Class of Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) Modulators

2011 Journal of Medicinal Chemistry
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Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core.

2011 Bioorganic & Medicinal Chemistry Letters
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Spiroimidazolidinone NPC1L1 inhibitors. Part 2: structure-activity studies and in vivo efficacy.

2010 Bioorganic & Medicinal Chemistry Letters
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Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume

2009 Journal of Medicinal Chemistry
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Discovery of a Peroxisome Proliferator Activated Receptor γ (PPARγ) Modulator with Balanced PPARα Activity for the Treatment of Type 2 Diabetes and Dyslipidemia

2009 Journal of Medicinal Chemistry
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Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening

2009 Bioorganic & Medicinal Chemistry Letters
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Extracellular loop C of NPC1L1 is important for binding to ezetimibe

2008 Proceedings of the National Academy of Sciences of the United States of America
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Madin-Darby Canine Kidney II Cells: A Pharmacologically Validated System for NPC1L1-Mediated Cholesterol Uptake

2008 Molecular Pharmacology
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Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.

2007 Journal of Pharmacological and Toxicological Methods
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Selective PPARγ modulators with improved pharmacological profiles

2005 Bioorganic & Medicinal Chemistry Letters
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