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Nalini Sadagopan

Pfizer

16

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1246

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Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.

2013 Bioorganic & Medicinal Chemistry Letters
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Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.

2011 ACS Medicinal Chemistry Letters
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Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

2011 Journal of Pharmacology and Experimental Therapeutics
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Development and validation of an LC-MS/MS method for quantification of cyclic guanosine 3',5'-monophosphate (cGMP) in clinical applications: a comparison with a EIA method.

2009 Journal of Chromatography B
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Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

2009 Chemistry & Biology
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A universal strategy for development of a method for absolute quantification of therapeutic monoclonal antibodies in biological matrices using differential dimethyl labeling coupled with ultra performance liquid chromatography-tandem mass spectrometry.

2009 Analytical Chemistry
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Analytical approaches to determine cytochrome P450 inhibitory potential of new chemical entities in drug discovery

2007 Journal of Chromatography B
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Circulating succinate is elevated in rodent models of hypertension and metabolic disease.

2007 American Journal of Hypertension
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An efficient approach for the rapid assessment of oral rat exposures for new chemical entities in drug discovery

2006 Journal of Pharmaceutical Sciences
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Evaluation of online extraction/mass spectrometry for in vivo cassette analysis

2005 Journal of Chromatography B
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Citations (16)