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David T. Dudley

Pfizer

27

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4348

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Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.

2011 ACS Medicinal Chemistry Letters
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Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice

2011 Pharmacology, Biochemistry and Behavior
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Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

2011 Journal of Pharmacology and Experimental Therapeutics
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The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

2008 Bioorganic & Medicinal Chemistry Letters
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Design and synthesis of phenethyl benzo[1,4]oxazine-3-ones as potent inhibitors of PI3Kinaseγ

2007 Bioorganic & Medicinal Chemistry Letters
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Erratum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition (Nature Structural and Molecular Biology (2004) 11(1192-1197))

2005 Nature Structural & Molecular Biology
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X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP

2004
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Peptides mek1 et mek2 modifies, cristal d'un complexe peptide/ligand/cofacteur contenant de tels peptides mek1 ou mek2 modifies et leurs procedes d'utilisation

2002
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Identification of a Novel Mitogen-Activated Protein Kinase Kinase Activation Domain Recognized by the Inhibitor PD 184352

2002 Molecular and Cellular Biology
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Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: role of transforming growth factor β and mitogen-activated protein kinases

2001 Biochemical Pharmacology
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Citations (16)