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Steven Staben

Genentech

42

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859

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Monomeric targeted protein degraders.

2020 Journal of Medicinal Chemistry
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Abstract PD4-14: GDC-0077 is a selective PI3Kalpha inhibitor that demonstrates robust efficacy in PIK3CA mutant breast cancer models as a single agent and in combination with standard of care therapies

2018 Cancer Research
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NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

2018 Nature Communications
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Selective inhibition of NF-kB inducing kinase (NIK) is therapeutically efficacious in IFNα-accelerated lupus nephritis prone mice

2017 Journal of Immunology
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Abstract 156: Preclinical characterization of GDC-0077, a specific PI3K alpha inhibitor in early clinical development

2017 Cancer Research
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Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

2017 Journal of Medicinal Chemistry
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The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

2016 Journal of Medicinal Chemistry
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Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors.

2014 Journal of Medicinal Chemistry
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Abstract DDT02-01: Discovery of GDC-0032: A beta-sparing PI3K inhibitor active against PIK3CA mutant tumors.

2013 Cancer Research
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Abstract A067: Targeting p21-activated kinases in breast cancer

2013 Molecular Cancer Research
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