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Lawren C. Wu

Genentech

47

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An Allosteric Anti-Tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

2019
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An Allosteric Anti-Tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

2019 Cell
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NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

2018 Nature Communications
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Selective inhibition of NF-kB inducing kinase (NIK) is therapeutically efficacious in IFNα-accelerated lupus nephritis prone mice

2017 Journal of Immunology
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Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.

2017 Bioorganic & Medicinal Chemistry Letters
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A CEACAM6-High Airway Neutrophil Phenotype and CEACAM6-High Epithelial Cells Are Features of Severe Asthma

2017 Journal of Immunology
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Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

2017 Journal of Medicinal Chemistry
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Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses

2016 Scientific Reports
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Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells.

2015 Proceedings of the National Academy of Sciences of the United States of America
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Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

2015 Science Signaling
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