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Rebecca Hong

Genentech

23

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1165

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RTK-dependent inducible degradation of mutant PI3K alpha drives GDC-0077 (Inavolisib) efficacy

2021 bioRxiv
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RTK-dependent inducible degradation of mutant PI3Kα drives GDC-0077 (Inavolisib) efficacy.

2021 Cancer Discovery
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Abstract PD4-14: GDC-0077 is a selective PI3Kalpha inhibitor that demonstrates robust efficacy in PIK3CA mutant breast cancer models as a single agent and in combination with standard of care therapies

2018 Cancer Research
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Let’s give them something to talk about: Exploring assessment language and culture

2018
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Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State

2018 Cell Metabolism
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Abstract 156: Preclinical characterization of GDC-0077, a specific PI3K alpha inhibitor in early clinical development

2017 Cancer Research
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Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

2017 Nature Communications
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Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

2016 Nature Chemical Biology
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Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

2015 Proceedings of the National Academy of Sciences of the United States of America
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Abstract 2672: Characterization of the enhanced potency of PI3K inhibitor taselisib (GDC-0032) in PI3K mutant cell lines and models

2015 Cancer Research
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