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    Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure-activity Relationship Study of Rigid Analogues of 2,4,6-Trisubstituted Pyridine Containing 5,6-Dihydrobenzo[h]quinoline Moiety
    Bulletin of the Korean Chemical Society (2011)
    Byeong-Seon JeongHo-Young ChoiYoungjoo KwonRadha KarkiEun‐Young LeeJung-Min NamYounghwa NaEun-Mi HaYoungjoo KwonEung-Seok Lee
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    Abstract:
    DNA topoisomerases are nuclear enzymes that transiently break one or two strands of DNA, passing a single or double stranded DNA through the break and again resealing the breaks which allow to solve various DNA topological problems ge-nerated during vital cellular proce sses such as replication, trans-cription, recombination, repair, chromatin assembly and chromo-some segregation.
    Keywords:
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    Moiety
    Structure–activity relationship
    Topics:
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    DNA topoisomerases are nuclear enzymes that transiently break one or two strands of DNA, passing a single or double stranded DNA through the break and again resealing the breaks which allow to solve various DNA topological problems ge-nerated during vital cellular proce sses such as replication, trans-cription, recombination, repair, chromatin assembly and chromo-some segregation.
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