[Primary lung neoplasm of rare incidence: giant cell carcinoma].
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Abstract:
Primary giant-cell carcinoma of the lung is an infrequent observation. It is distinguished clinically solely its fairly rapid development but otherwise it does not seem to have any predilection for localization, age or sex. Histologically, differential diagnosis with othe tumours such as angiosarcoma, rhabdomyosarcoma, chorioepithelioma and others is of interest. Three cases of primary giant-cell carcinoma of the lung are reported and the various clinical and anatomopathological aspects discussed.Keywords:
Neoplasm
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Immunostaining
Epithelioma
Large cell
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Complete response
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Primary giant-cell carcinoma of the lung is an infrequent observation. It is distinguished clinically solely its fairly rapid development but otherwise it does not seem to have any predilection for localization, age or sex. Histologically, differential diagnosis with othe tumours such as angiosarcoma, rhabdomyosarcoma, chorioepithelioma and others is of interest. Three cases of primary giant-cell carcinoma of the lung are reported and the various clinical and anatomopathological aspects discussed.
Neoplasm
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Objective To its diagnosis and explore the histopathologic and immunohistochemical characteristics of small cell carcinoma of the lung and its diagnosis and differential diagnosis.Methods We observed the histopathologic and immunohistochemical results in 8 cases of small cell carcinoma and the related literature was reviewed.Rusults Histologically,the majority of the tumor was composed of cords or nest or sheets or loose aggregates of small cell;it had minor component of squamous and glandular differentiation.Immunohistochemically,the tumor cells were positive CK、CEA,the partly small cells were positive for Syn、CgA.Conclusions Small cell carcinoma of the lung is a malignant tumor.It has a characteristic histopathologic pattern.Differential diagnosis of it includes lymphoma,primitive neuroectodermal tumour,Merkel cell carcinoma,non-small carcinoma,large cell neuroendocrine,carcinoid.
Large cell
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Large cell
Lung biopsy
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Polymorphous hemangioendothelioma (PH) is an uncommon vascular neoplasm of borderline malignant potential characterized by a considerable variability in patterns of cellular growth. Morphologically, PH may be confused with other lesions, from benign vasoformative neoplasms and reactive inflammatory conditions to malignancies such as angiosarcoma or squamous cell carcinoma. Most occur in the lymph nodes, and to the best of our knowledge, lesions involving the maxillary soft tissue have not been described in the literature to date. A potential for local recurrence, as well as the ability to metastasize, has been for this type of neoplasm. Here we reported on a rare case of polymorphous hemangioendothelioma which presented as an asymptomatic subcutaneous mass in the right zygomatic region of a 22-year-old white female. We discuss the histopathological aspects of this tumor, with emphasis on the role of immunohistochemical analysis in differential diagnosis.
Hemangioendothelioma
Neoplasm
Metastatic carcinoma
Epithelioid Hemangioendothelioma
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Objective To investigate the clinicopathologic characteristics of the small cell lung carcinoma.Methods The clinical data,pathological findings,and results of immunohistochemical staining were retrospectively studied in 9 cases of small cell lung carcinoma.Results In all the types of lung carcinomas,small cell lung carcinoma accounted for 14.8%;The average age was 63.5 years old;The tumor cells were positive for NSE,CgA,Syn and CD56,but negative for LCA.Conclusion Small cell lung carcinoma is a seriously malignant tumor,with rapid progression and early metastasis.Neuroendoefine markers are positive to this tumor.
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Objective To explore the relationship between the expression of tumor-associated antigen RCAS1(receptor-binding cancer antigen expressed on SiSo cells) and the clinical pathological factors in non-small cell lung carcinoma. Methods Immunohistochemical SABC method was used to detect the expression of RCAS1 in 61 non-small cell lung carcinoma tissues, 10 benign lung tissues and 10 normal lung tissues. The relationship between the expression and clinical pathologic charactors was analyzed. Results The positive rate of RCAS1 in non-small lung carcinoma was significantly higher than that in normal lung tissues (P 0.05). But there was no significant difference between the expression or rate of RCAS1 in non-small cell lung carcinoma and benign lung tissues (P 0.05). RCAS1 expression in non-small cell lung carcinoma was correlated with tumor differentiation and clinical staging (P 0.05). Conclusions RCAS1 may participate in the onset and progression of non-small cell lung carcinoma. RCAS1 may be a new biomarker in the diagnosis, treatment and prognostic evaluation of non-small cell lung carcinoma.
Clinical Significance
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Large cell
Carcinoid tumors
Carcinoid tumour
Neuroendocrine carcinoma
Oat cell carcinoma
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