[Iron metabolism in patients with different variants of pulmonary tuberculosis].
4
Citation
0
Reference
10
Related Paper
Citation Trend
Abstract:
Prior to treatment, 48 patients with different forms of pulmonary tuberculosis were examined. Serum iron concentrations, total iron-binding capacity of the serum (STIBC), its unsaturated iron-binding capacity (SUSIB), serum transferrin iron saturation coefficient (SC), total protein in the serum, red blood cells, hemoglobin, colour index were determined. All the parameters under study were in the normal range in patients with a favourable involutional course of pulmonary tuberculosis. In patients with acutely progressive pulmonary tuberculosis, serum iron levels, STIBC, SC were drastically decreased, while SUSIB was in the normal range. All this was attended by phenomena of hypochromic anemia. The pattern of the found changes leads to the conclusion that patients with acutely progressive tuberculosis develop iron-redistributing anemia caused by the changes in the amount and quality of transferrin, iron binding during free radical processes and mobilization of the antioxidant defense system rather than true iron deficiency.Keywords:
Transferrin saturation
Total iron-binding capacity
Cite
The value of serum ferritin in assessing iron status was studied in 192 preschool age children between the ages of 3 and 60 months. Children were considered to have iron deficiency if the transferrin saturation was less than 16% and the peripheral smear revealed microcytosis and hypochromia. Anemia was present when hemoglobin level was 10.5 g/dl. According to this criteria, 46% of children screened had either iron deficiency (11.5%) or iron deficiency anemia (34.4%). Mean serum ferritin for the iron deficiency anemia group was 39.1 ng/mg as compared to 41.7 ng/ml for the iron deficiency group and 84.7 ng/ml for the normal group. Even though the serum ferritin level was lower in the iron deficiency group, the difference in the means did not reach statistical significance. Furthermore, only 30% of children who had either iron deficiency or iron deficiency anemia had serum ferritin level of less than 12 ng/ml, the level considered diagnostic for iron deficiency. It can be concluded that serum ferritin cannot be used alone for iron status determination. Multiple parameters will make the assessment more reliable.
Microcytosis
Transferrin saturation
Cite
Citations (16)
Transferrin saturation
Cite
Citations (7)
Background: Iron deficiency anemia (IDA) is most common cause of anemia in pregnancy. In order to prevent this iron supplementation is routinely practiced as a prophylactic measure in pregnant women all over. The biochemical parameters assessed in IDA comprise an iron profile evaluation which consists of estimation of serum ferritin, serum iron, total iron binding capacity(TIBC), serum transferrin levels and calculation of transferrin saturation. These biochemical parameters are subjected to variations due to maternal adaption phenomenon. Aim: In the current study we have chosen three iron indices, serum iron, serum TIBC and transferrin saturation percent to note their performance in diagnosing and monitoring the response to iron therapy in pregnant women. Methodology: The study population are thirty- six pregnant women in their early second trimester, who are diagnosed with mild iron deficiency anemia (Hemoglobin between 9 and 11 g %). Iron parameters, serum iron, serum TIBC and transferrin saturation levels were analyzed in these women. They are then given oral iron preparation in the form of Ferrous sulphate for a period of twelve weeks. After this the Hemoglobin level, serum iron, TIBC and transferrin saturation levels are re-analyzed in these women. Results: The hemoglobin levels increased (p= 0.002). as expected after oral iron intake. Serum iron levels improved from 58.19±39.07 to 64.78±34.96 μg/dl. Serum TIBC value before supplementation 234.22±134.49 increased to 437.33±94.95 after, which contradicts the expected pattern seen in response to therapy in general population. Similarly absurdity prevails in transferrin saturation index levels which dropped from 36.8 ± 31.8 to 16.3 ± 10.6. Conclusion: The iron status during pregnancy is highly influenced by the maternal changes. And a blind interpretation of the report can lead to erroneous diagnosis. The interpretation of values should be based on the trimester specific reference ranges during pregnancy.
Transferrin saturation
Total iron-binding capacity
Cite
Citations (0)
BACKGROUND: Iron deficiency (ID) anemia remains a common cause of anemia in young children. However, the more significant than anemia itself is the ID without anemia that also adversely affect neurocognitive development and unfortunately some of these effects may be irreversible. AIM: This study is a cross-sectional study aimed to asses iron status in preschool children with normal hemoglobin (Hgb) level attending Assiut University Children Hospital. METHODS: The cross-sectional study including 68 apparently healthy children aged 1–6 years old during the period from January 1, 2015 to June 30, 2015, They were subjected to detailed history, physical examination, and the following laboratory investigations: Complete blood count, Serum iron, Total Iron Binding Capacity, Serum ferritin, and Transferrin saturation. RESULTS: Low serum ferritin and low transferrin saturation were detected in 41.2% and 47% respectively of our studied children who have normal Hgb levels. CONCLUSION: Normal Hgb doesn’t exclude ID that should be screened in healthy children to prevent the possible long-term effects of ID on their cognation and mental development.
Transferrin saturation
Neurocognitive
Complete blood count
Total iron-binding capacity
Cite
Citations (1)
Comparison of iron status markers in iron deficiency anemia and anemia of chronic kidney diseases - IJCBR- Print ISSN No: - 2394-6369 Online ISSN No:- 2394-6377 Article DOI No:- 10.18231/j.ijcbr.2019.055, International Journal of Clinical Biochemistry and Research-Int J Clin Biochem Res
Cite
Citations (0)
Objective:To evaluate the clinical significance of iron parameters composed of Serum iron (SI) , Total iron-binding capacity (TIBC) , Transferrin saturation (TS), Serum ferrin (SF), Soluble transferrin receptor (sTFR) , Mean corpuscular volume (MCV) and Erythrocyte hemoglobin distribution width (RDW) in dignosis of Iron deficiency anemia(IDA). To identify the optimal cutoff point of SF measured with ELISA. Method:Two hundred and fifty-two patients with anemia from out-patient clinic or inpatient department entered the study. Based on the iron staining result of bone marrow smear as the gold standard for iron deficiency, patients were classified into two groups; IDA group and Non-ID A group. Iron parameters are SI, TIBC, TS, SF, sTFR, blood routine, bone marrow iron staining, ROC curve were used to evaluate iron parameters and to identify their optimal critical point. Result:The values of area under the curve (AUC) of each iron parameter are as followings: SI 0. 54(95%CI:0. 36 -0.71), TIBC0. 89(95 %CI: 0.75- 1.03), TS 0. 68(95%CI: 0. 58-0. 78), SF 0. 87(95%CI:0. 77 -0. 97), sTFR0. 92(95%CI:0. 84-1.00), MCV 0. 82(95%CI:0. 70-0. 94), RDW 0. 81(95%CI:0. 68-0. 94). sTFR has the highest value of AUC, and the order from high to low is AUCsTFR, AUCTIBC, AUCSF, AUCMCV, AUCRDW, AUCTS, AUCSI. The optimal critical point of SF assayed with ELISA is 50 ug/L. At that point, the sensitivity is 0. 85 and the specificity is 0. 96. Conclusion:①Among the parameters of SI, TIBC, TS, SF, sTFR, MCV and RDW, sTFR is the best for diagnosis of iron deficiency. The order of diadynamic value of these parameters is sTFRTIBCSFMCVRDWTSSI.②The optimal critical point of SF assayed with ELISA is 50 ug/L.
Transferrin saturation
Soluble transferrin receptor
Total iron-binding capacity
Cite
Citations (0)
The purpose of this study was to compare iron related indices in patients with iron deficiency anemia and chronic causative diseases between geriatric older than 65 years and adult, nongeriatric younger than 65 years groups. Iron deficiency anemia (IDA) cases with chronic disorders from Youngdong Severance hospital from June, 1991 to April, 1994, older than 65 years (17 cases), and younger than 65 years (29 cases) were analysed with iron related indices. Mean hemoglobin was 7.8 +/- 2.2 g/dl in geriatric IDA and 8.0 +/- 1.8 g/dl in adult IDA without significant difference. RDW value was 19.5 +/- 2.6 in geriatric IDA and 18.4 +/- 3.2 in adult IDA with no significant difference. Serum iron and transferrin saturation between geriatric IDA were 22.7 +/- 12.3 ug/dl, 6.7 +/- 4.1% and 28.6 +/- 16.6 ug/dl, 7.1 +/- 4.4% in adult IDA with no significant difference, but TIBC was significantly lower (P = 0.011) in geriatric IDA than in adult IDA patients (357.2 +/- 83.2, 413.6 +/- 54.0 ug/dl). In normal elderly people, serum ferritin was 152.5 +/- 95.4 ng/ml in male and 111.1 +/- 54.1 ng/ml in female with range 19.8 approximately 367.7 ng/ml in male and 11.7 approximately 238.7 ng/ml in female and was higher than that of normal adult in both sexes (147.0 +/- 108.0, 35.3 +/- 20.5 ng/ml) (P = 0.045). Serum ferritin in geriatric IDA was 13.8 +/- 11.8 ng/ml and 5.7 +/- 4.0 ng/ml in adult IDA with significant difference(P = 0.001). The Upper margin for geriatric IDA was 37 ng/ml with 95% confidence interval. In the diagnosis of geriatric IDA with causative diseases, we should consider that TIBC does not increase and the upper margin for serum ferritin is suggested to increases up to 37 ng/ml.
Transferrin saturation
Total iron-binding capacity
Cite
Citations (7)
The prevalence and causes of anemia were studied in 294 Druze children aged 10 months to six years. The hemoglobin level was less than 11.0 g/dl in 19%; none of these anemic children had folate deficiency. Iron deficiency, diagnosed on the basis of abnormal values for at least two independent laboratory parameters, was the cause of anemia in all but two cases. The Pearson correlation coefficient for hemoglobin was highest with mean corpuscular volume, erythrocyte protoporphyrin, serum iron, transferrin saturation, total-iron-binding capacity, and serum ferritin. Mean corpuscular hemoglobin and transferrin saturation were abnormal in greater than 90% of anemic children, whereas serum ferritin and total-iron-binding capacity were abnormal in only 70%. In view of its limited sensitivity, serum ferritin appears to be a less useful diagnostic aid in iron-deficiency anemia than other, less expensive laboratory methods.
Transferrin saturation
Total iron-binding capacity
Mean corpuscular hemoglobin
Cite
Citations (0)
To investigate the link between serum erythroferrone (ERFE) levels and iron status parameters in pediatric patients with iron deficiency anemia.The study consisted of 66 children (36 with iron deficiency anemia and 30 healthy age- and gender-matched controls) who were investigated for serum levels of iron, total iron-binding capacity (TIBC) using automated chemistry analyzer, serum ferritin using electrochemiluminescence immunoassay and ERFE by specific enzyme-linked immunosorbent assay (ELISA) kit.Serum erythroferrone levels in iron deficiency anemia patients (191.55 ± 83.74 pg/mL) were significantly higher than those in control group (42.22 ± 16.55 pg/mL) (P < .001). In iron deficiency anemia patients, serum erythroferrone concentrations correlated negatively with hemoglobin concentration (r = -.39; P = .01), serum iron (r = -.63; P < .001), transferrin saturation (r = -.66; P < .001), and serum ferritin (r = -.46; P = .004) while positive correlation was observed between serum erythroferrone concentrations and TIBC (r = .62; P < .001) CONCLUSION: The newly identified erythroferrone hormone may act as physiological hepcidin suppressor in cases with iron deficiency anemia, and so it may serve as a specific promising target of therapy in such cases.
Transferrin saturation
Total iron-binding capacity
Cite
Citations (31)
Prior to treatment, 48 patients with different forms of pulmonary tuberculosis were examined. Serum iron concentrations, total iron-binding capacity of the serum (STIBC), its unsaturated iron-binding capacity (SUSIB), serum transferrin iron saturation coefficient (SC), total protein in the serum, red blood cells, hemoglobin, colour index were determined. All the parameters under study were in the normal range in patients with a favourable involutional course of pulmonary tuberculosis. In patients with acutely progressive pulmonary tuberculosis, serum iron levels, STIBC, SC were drastically decreased, while SUSIB was in the normal range. All this was attended by phenomena of hypochromic anemia. The pattern of the found changes leads to the conclusion that patients with acutely progressive tuberculosis develop iron-redistributing anemia caused by the changes in the amount and quality of transferrin, iron binding during free radical processes and mobilization of the antioxidant defense system rather than true iron deficiency.
Transferrin saturation
Total iron-binding capacity
Cite
Citations (4)