Iron related indices in iron deficiency anemia of geriatric Korean patients
7
Citation
0
Reference
10
Related Paper
Citation Trend
Abstract:
The purpose of this study was to compare iron related indices in patients with iron deficiency anemia and chronic causative diseases between geriatric older than 65 years and adult, nongeriatric younger than 65 years groups. Iron deficiency anemia (IDA) cases with chronic disorders from Youngdong Severance hospital from June, 1991 to April, 1994, older than 65 years (17 cases), and younger than 65 years (29 cases) were analysed with iron related indices. Mean hemoglobin was 7.8 +/- 2.2 g/dl in geriatric IDA and 8.0 +/- 1.8 g/dl in adult IDA without significant difference. RDW value was 19.5 +/- 2.6 in geriatric IDA and 18.4 +/- 3.2 in adult IDA with no significant difference. Serum iron and transferrin saturation between geriatric IDA were 22.7 +/- 12.3 ug/dl, 6.7 +/- 4.1% and 28.6 +/- 16.6 ug/dl, 7.1 +/- 4.4% in adult IDA with no significant difference, but TIBC was significantly lower (P = 0.011) in geriatric IDA than in adult IDA patients (357.2 +/- 83.2, 413.6 +/- 54.0 ug/dl). In normal elderly people, serum ferritin was 152.5 +/- 95.4 ng/ml in male and 111.1 +/- 54.1 ng/ml in female with range 19.8 approximately 367.7 ng/ml in male and 11.7 approximately 238.7 ng/ml in female and was higher than that of normal adult in both sexes (147.0 +/- 108.0, 35.3 +/- 20.5 ng/ml) (P = 0.045). Serum ferritin in geriatric IDA was 13.8 +/- 11.8 ng/ml and 5.7 +/- 4.0 ng/ml in adult IDA with significant difference(P = 0.001). The Upper margin for geriatric IDA was 37 ng/ml with 95% confidence interval. In the diagnosis of geriatric IDA with causative diseases, we should consider that TIBC does not increase and the upper margin for serum ferritin is suggested to increases up to 37 ng/ml.Keywords:
Transferrin saturation
Total iron-binding capacity
Background: iron overload is the most common complication in patients who revived multiple red blood transfusions to correct the anemia.
Objective this study aimed to evaluate the iron profile (serum iron, ferritin, total iron binding capacity (TIBC) and transferrin saturation percentage) in Sudanese patients with cardiovascular disorders, who revived multiple red blood transfusions.
Material and methods this was a case control study conducted during August 2015, in Alneelain University, Faculty of Medical Laboratory Science. A total of 100 participants were enrolled in this study, 60 were Sudanese patients diagnosed with cardiovascular disorders and who received multiple blood transfusions at Alshaab Teaching Hospital Khartoum, Sudan; their mean age was (50.6+12.7) years, designated as a patient’s group. Other 40 subjects were normal healthy who received no blood transfusions as control group; their mean age was 45.5+11.4 years. Venous blood was collected from all participants, and then the serum was prepared from clotted blood. The iron profile (serum ferritin, serum iron and total iron binding capacity) was carried out using automated chemical analyzer (MINDRAY BS 200-China).Data were analyzed employing statistical package for social sciences (SPSS) version 20. The p value less than 0.05 was considered significant.
Result this study showed that the serum iron and serum ferritin were statistically significantly higher while the TIBC and transferrin saturation percentage were statistically significantly lower in cardiovascular patients who received regular blood cell, compared with those normal ho received regular packed cell with p value (0.01,0.04,0.04 and 0.04) respectively.
Conclusion iron overload was present in Sudanese cardiovascular patients who received no multiple blood transfusion compared to those normal who received no blood cell.
Total iron-binding capacity
Transferrin saturation
Venous blood
Cite
Citations (0)
Background:Iron is a vital constituent of cells but in excess may be harmful and is associated with a raised risk for some malignant diseases including breast cancer. We aimed to study changes in iron profile in Sudanese females newly diagnosed with breast cancer.Methods: A case- control study in which serum iron, Total Iron Binding Capacity (TIBC), and transferrin saturation percent were measured for fifty females with breast cancer referred to Khartoum Oncology Hospital and seventy apparently healthy females, using manual method (IRON-FERROZINE). Results: Mean age was 47years and 42years in cases and control, respectively and the mean of parity was 4 in both groups. Mean of serum iron ±SD in case group was 244.30 ± 151.598(µg/dL)and in control group was 57.59 ± 43.191(µg/dL) (P. value = 0.000). Mean of TIBC ±SD in cases was 412.98 ± 177.460(µg/dL)and in controls it was 403.71 ± 168.765(µg/dL) (P.value = 0.838). The mean of transferrin saturation percent ± SD in cases was 61.08 % ±41.523 and in controls was 223.23 % ±149.195 (P.value=0.000). The mean of TIBC in grade I 343.00(µg/dL), 467.10(µg/dL) in grade II and 321.25(µg/dL) in grade III (P.value 0.019).Conclusion: There is a statistically significant increase in the mean of serum iron and decrease in transferrin saturation percent in women with breast cancer. TIBC vary significantly according to histopathological grade. Serum iron and transferrin saturation percent may be helpful as biochemical risk markers for breast cancer and TIBC may act as a predictor of disease grade.
Transferrin saturation
Total iron-binding capacity
Mean value
Cite
Citations (4)
We surveyed 140 clinical chemistry laboratories in Australia to establish which laboratory methods they used to determine serum iron status: 125 measured serum iron (Fe), 85 measured transferrin (TRF), 47 measured total iron-binding capacity (TIBC), and 14 measured both TRF and TIBC. Of the 55 laboratories routinely reporting TRF saturation (TS), 16 calculated TS directly as (Fe/TIBC) x 100, and 9 used [Fe/(TRF x 2)] x 100. Thirty laboratories measured TRF and converted it to an equivalent TIBC concentration; the derived TIBC was then used to calculate TS. We measured iron, TIBC, and TRF concentrations in 94 control subjects, 59 patients with alcoholic liver disease (ALD), and 20 with proven genetic hemochromatosis (GH). TS was compared with a transferrin index (TI = Fe/TRF) to determine whether both methods were sensitive for GH screening and which method gave the fewest false-positive results with discrimination limits of > 55% and > 1.0, respectively. All GH patients were detected by both TS and TI at these limits. One control subject had a TI > 1.0, whereas three control subjects had a TS > 55%. Nine patients with ALD had a TI > 1.0 and 11 ALD patients had a TS > 55%. Some iron-overload patients had lower than expected TS values compared with TI, possibly because of ferritin interference in the TIBC assay. Also, the precision of the TRF assay was better than that of the TIBC assay: CVs of 1.85-3.68% vs 6.17%. We therefore recommend that calculated TI replace TS in screening for iron overload.
Transferrin saturation
Total iron-binding capacity
Cite
Citations (79)
Male blood donors from three population groups (Indian, Black, White) who showed neither microcytosis nor levels of serum ferritin or transferrin saturation suggestive of iron deficiency were matched in 3's 1 from each population, for age, number of previous blood donations, and serum ferritin. Three groups of individuals of similar iron status were thus obtained, in whom mean serum iron and total iron-binding capacity as well as red cell indices were compared. The Indian group had smaller red corpuscles, and more of them, than either of the other groups; they also had significantly higher mean total iron-binding capacity. The Black group had a lower mean level of serum iron than the other two, coupled with a total iron-binding capacity greater than in the Whites but less than in the Indians; as a result, both the Indian and Black groups had a lower mean transferrin saturation than the White. The mean level of haemoglobin was significantly lower in the Black group than in the other two. It is unlikely that any of these differences is due to iron deficiency.
Microcytosis
Total iron-binding capacity
Transferrin saturation
Cite
Citations (0)
The aim of this study was to investigate serum iron parameters, and copper and iron deficiency anemia in ewes infected with gastro-intestinal parasites. This study was conducted with 60 pregnant Akkaraman ewes. In the statistical analyses, values obtained from both parasite infected and uninfected ewes were compared. Significant decreases were observed in PCV (P < 0.05), Hb (P < 0.05), RBC (P < 0.05), total protein (P < 0.05), albumin (P < 0.05), globulin (P < 0.05), and MCHC (P < 0.01), and a significant increase was seen in the WBC value (P < 0.05) in the parasite infected group. Furthermore, the parasite infected group had lower serum Fe (P < 0.001), TS % (P < 0.001), and serum Cu (P < 0.01) levels, and had higher UIBC values (P < 0.05) compared to the values obtain from the uninfected group. Therefore, in addition to antiparasite drug treatment in parasite infected pregnant ewes, iron preparations should also be administered in order to treat iron deficiency. Ozet: Bu araflt›rman›n amac›; mide-ba¤›rsak parazitleriyle enfekte gebe akkaraman ›rk› koyunlarda serum demir parametreleri, bak›r ve demir eksiklii anemisini araflt›rmakt›r. Araflt›rma 60 gebe akkaraman ›rk› koyun uzerinde yurutuldu. ‹statistiksel analizde, parazitli koyunlarda elde edilen deerler parazitle enfekte olmayan koyunlar›n deerleriyle karfl›laflt›r›ld›¤›nda PCV (P < 0,05), Hb (P < 0,05), RBC (P < 0,05), total protein (P < 0,05), albumin (P < 0,05), globulin (P < 0,05), MCHC (P < 0,01) deerlerinde azal›fl ve WBC deerinde (P < 0,05) art›fl gozlendi. Ayr›ca parazitli grubun parazitsiz gruba gore daha dufluk serum Fe (P < 0,001), % TS (P < 0,001), serum Cu (P < 0,01) deerlere ve daha yuksek UIBC (P < 0,05) sahip olduu saptand›. Sonuc olarak; parazitli gebe koyunlarda antiparaziter ilac uygulamalar›n ek olarak ayn› zamanda demir eksikliini tedavi etmek icin demir preparatlar›
Transferrin saturation
Total iron-binding capacity
Saturation (graph theory)
Gastro-
Cite
Citations (16)
The study was conducted on 130 healthy and 72 affected with iron deficiency anemia (IDA) by used local breed goats to determine serum iron, total iron binding capacity (TIBC), unbound iron binding capacity (UIBC), copper concentration and transferrin saturation (TS%). The 130 normal goats (40 males and 90 females). while 72 diagnosed iron deficient anemic goats (18males and 54females), both groups aged 6 months- 4 years in Najaf governorate. Blood samples were collected from the jugular veins into plain tubes during October 2013 till February2014, and the separated sera were directly used for chemical investigation. Result showed in normal and iron deficient anemic goats; Serum iron concentration was 7-17.9 and 11.8±0.22, 1.2-6.9 and 4.3±0.17 respectively, TIBC 67.5-107.3 and 89.7±0.69, 67.3-265 and 112.4±4.35 respectively ,UIBC 59.1-94.9 and 78±0.69, 60.9-260 and 108.1±4.36 respectively, TS% 7.4-20 and 13.1±0.25, 0.90-10.1 and 4.1±0.23 respectively and serum copper 1.1-4.6 and 2.4±0.05, 0.7-3.0 and 1.7±0.06 respectively.However, There were a significant (P<0.05) decrease in serum iron, TS% and copper, while there was a significant increase (P<0.05) in serum TIBC and UIBC of IDA goats as compared with normal control. Also, a significant differences(P<0.05) between males and females, as well as, in subgroups of normal and anemic goats have been recorded . In conclusion the present data recorded reference ranges of some biochemical parameters in local breed goats with a significant differences between normal, anemic ,males and females, and in different physiologic status .
Total iron-binding capacity
Transferrin saturation
Cite
Citations (2)
This case control cross sectional study was carried out in the department of Biochemistry, Mymensingh Medical College in collaboration with Cardiology department of Mymensingh Medical College Hospital, Mymensingh during the period of July 2004 to June 2005. The aim of the study was to explore the status of body iron among acute myocardial infarction (AMI) patients in Bangladesh as a means to monitor the possibility of management of these patients. A total of 100 subjects were selected and were grouped as Group I (50 healthy Control subjects) and Group II (50 subjects of AMI Cases). Serum iron, total iron binding capacity (TIBC) & transferrin saturation were estimated from each sample. Statistical analysis was done by using SPSS windows package. Among the groups, mean±SD of Group I serum iron, TIBC & transferrin saturation were 71.84±9.10, 336.66±35.39 & 21.73±4.88 respectively and of Group II serum iron, TIBC & transferrin saturation were 137.55±18.22, 267.99±34.97 & 52.40±11.74 respectively. By comparing Group I with Group II highly significant difference were found in case of serum iron (p<0.001), TIBC (p<0.001) and transferrin saturation (p<0.001). It is evident from the study that body iron (serum iron, TIBC & transferrin saturation) level significantly increases among acute myocardial infarction patients in Bangladesh.
Transferrin saturation
Total iron-binding capacity
Cite
Citations (0)
To determine the diagnostic accuracy of serum iron and total iron binding capacity (TIBC) in detection of iron deficiency.Descriptive, analytical study.Department of Chemical Pathology and Endocrinology, from January 2013 to October 2015.Data of 1,815 patients with results of serum iron, TIBC and ferritin from January 2013 to October 2015 was retrieved from Laboratory information System (LIMS) of AFIP. Diagnostic Accuracy Studies (STARD) guidelines were followed. Subjects of either gender, aged 1 - 68 years were included. Cases with raised serum ferritin levels (male > 336 ng/ml, female > 307 ng/ml) were excluded. Serum Ferritin was taken as gold standard with specificity of 99% and sensitivity of 80% at concentration of 30 ng/ml. Transferrin saturation was determined by dividing serum iron by TIBC and multiplying by 100.Out of 1,815 subjects, 931 (51.29%) were males and 884 (48.71%) were females. The median age of the patients were 29.1 years (Inter-quartile range, IQR 19.1). Taking ferritin as gold standard, the sensitivity and specificity of serum iron was 63.5% and 38.6%, respectively; while that of TIBC was 64.5 % and 42.8%, respectively. Ferritin showed poor correlation with iron, TIBC and transferrin saturation.Serum iron and TIBC give no additional information in the diagnosis of iron deficiency anemia and these tests are redundant for the diagnosis of iron deficiency state, if serum ferritin is available.
Total iron-binding capacity
Transferrin saturation
Cite
Citations (12)
Serum levels of iron and transferrin, and percent saturation of total iron binding capacity (TIBC) and latent iron binding capacity were estimated in 89 women in their I, II and IIIrd trimester of pregnancy. Associated infective, metabolic or degenerative diseases were excluded after clinical examination. The women were divided into three groups of normal, mildly anaemic and severely anaemic. In the normal group serum iron levels were within normal range irrespective of period of gestation, whereas in the anaemic groups, these were lower. Serum transferrin levels were significantly low in II and III trimester of pregnancy of anaemic women. Percent saturation of TIBC was even lower than normal in Ist trimester of pregnancy in normal pregnancy (27.12%). However in mild anaemic there was significant fall and in severe anaemia, it was very low, leaving a vast latent iron binding capacity. The decrease of % saturation of TIBC even in normal pregnant women is indicative of inherent poor stores, which may be due to defective diet.
Transferrin saturation
Total iron-binding capacity
Cite
Citations (5)
Prior to treatment, 48 patients with different forms of pulmonary tuberculosis were examined. Serum iron concentrations, total iron-binding capacity of the serum (STIBC), its unsaturated iron-binding capacity (SUSIB), serum transferrin iron saturation coefficient (SC), total protein in the serum, red blood cells, hemoglobin, colour index were determined. All the parameters under study were in the normal range in patients with a favourable involutional course of pulmonary tuberculosis. In patients with acutely progressive pulmonary tuberculosis, serum iron levels, STIBC, SC were drastically decreased, while SUSIB was in the normal range. All this was attended by phenomena of hypochromic anemia. The pattern of the found changes leads to the conclusion that patients with acutely progressive tuberculosis develop iron-redistributing anemia caused by the changes in the amount and quality of transferrin, iron binding during free radical processes and mobilization of the antioxidant defense system rather than true iron deficiency.
Transferrin saturation
Total iron-binding capacity
Cite
Citations (4)