[Liberation of the active ingredient from isoprenaline (Izadrin) containing suppositories].
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The paper examines the formulation of hydrogel on the base of a synthetic polymer containing a local anaesthetic and a mass-produced drug in the form of a solution with an antiphlogistic effect. It aimed to prepare a hydrogel of a suitable composition with suitable flow properties and drug release, the active ingredient being lidocaine hydrochloride. Besides the role of a synthetic polymer which ensures that the active ingredient remains at the affected site, an important role in the formulation is played by the presence of an artificial sweetener, which to a great extent as a taste correcting agent of the unpleasant taste of the active ingredient influences the compliance of many patients. The study examined the effect of concentration of the artificial sweetener xylitol on the liberation of the active ingredient from prepared hydrogels. The optimum concentration of the artificial sweetener was adjusted to a degree which does not affect the qualitative properties of the active ingredient.lidocaine hydrochloride, xylitol, hydrogel, liberation.
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Prednisolone
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Objective:To develop an HPLC method for the determination of droplet size distribution,content of ac- tive ingredient in an actuation and content of isopreualine hydrochloride aerosol.Methods:The chromatographic conditions were:Shim Pack VP-ODS column(250 mm×4.6 mm,5 μm),the mixture that dissolved 1.76 g of so- dium 1-heptanesulfonate in 800 ml,of water and 200 mL methanol (adjust with 1 mol·L~(-1) phosphoric acid to a pH of 3.0±0.1) as mobile phase with detection wavelength of 280 nm.Tire determination of droplet size distribu- tion was analyzed by devices for aerodynamic size distribution,following the standard ChP procedure.Results:The calibration curve was linear within the range of 3.5-700 μg·mL~(-1) (r=0.9999) for isoprenaline hydrochloride. The average recovery rate was 99.3%,98.7% and 98.2% respectively(n=9).Conclusion:The method is simple, sensitive,accurate and suitable for determination of isoprenaline hydrochloride aerosol and its content of active in- gredient in an actuation and droplet size distribution.As the results,the quality of isoprenaline hydrochloride has to be improve.
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The results show that N application will increase the yield of raw material and content of medical active ingredient. 25 kg/667m2 of urea application can reach the peak of biological and raw material yield, 6-10 kg/667m2 of urea application can reach the peak of medical active ingredient content, 20 kg/667m2 of urea application can reach the peak of active ingredient yield. Too much N causes the decrease of yield, active ingredient content, economical coefficient and N availability. N application can also regulate the ratio of L-camphol and the oil in the active ingredient.
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Matrix tablets with a dispersed active ingredient are the simplest concept in the design of dosage forms with modified drug release. If they contain a swelling polymer as an auxiliary substance, the release from these systems, after initial liberation of a portion of the active ingredient from the surface, takes place by diffusion, erosion, or a combination of both mechanisms in dependence on the solubility of the contained active ingredient. Although hydrophilic matrix tablets have become a well-tried and widely used dosage form with retarded effects, their research continues and new auxiliary substances and their combinations are being tested. The present paper reviews the knowledge published in this field in recent years.
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Granule (geology)
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