Human papilloma virus type 16 infection and the early onset of cervical cancer
Akihiro KarubeMasahiro SasakiHidenori TanakaOsamu NakagomeRajvir DahiyaSeiichiro FujimotoToshinobu Tanaka
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Papillomaviridae
Papillomaviridae
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The occurrence of cervical cancer is the result of long-term synergy from a variety of carcinogenic factors. Human papilloma virus (HPV), the main biological cause of cervical cancer, is closely related to the occurrence of cervical cancer, while HPV E6/E7 protein plays an important role in the malignant transformation of cervical cancer. This article summarizes the carcinogenic mechanism of HPV E6/E7 and application in cervical cancer screening, and reviews the targeting therapy aiming at HPV E6/E7.
Key words:
Human papilloma virus; E6/E7 protein; Cervical neoplasms; Targeting therapy
Malignant Transformation
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The incidence of invasive cervical cancer and consequently mortality decreased due to adequate screening programmes in Canada from 1969 to 2003. Systematic cervical screening programmes similar to those in Europe should be implemented throughout Canada. The new techniques, including a liquid-based cytology, associated or not with identifying human papilloma virus (HPV), allow the best results in prevention and early diagnosis of cervical cancer and high-grade squamous intraepithelial lesions (HSIL). In the future a vaccine against HPV type 16 could reduce the incidence of cervical cancer worldwide.
Cervical screening
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Squamous papilloma is the most common benign oral epithelial lesion, and it is well known to be associated with human papilloma virus 6 and 11. Here, we report a case of squamous papilloma associated with human papilloma viruses (HPV)-32 in a 4-year-old boy who presented with a verrucous lesion on the lower lip. HPV-32 is often associated with a rare benign condition focal epithelial hyperplasia (FEH). A limited number of lesions and the absence of characteristic histology ruled out FEH in our patient. To the best of our knowledge, the association of oral squamous papilloma with HPV-32 is hitherto unreported.
Papillomaviridae
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Objective To understand human papilloma virus(HPV)infection situation of women in the east area of Guangdong.Methods HPV of 569 women in the east area of Guangdong were examined by gene chip technique.Results Of 569 cases investigated,275 cases were HPV positive(48.3%),183 cases were single HPV type infection and 67 cases were double HPV types infection and 25 cases were multiple HPV types infection respectively.In 275 HPV positivecases,there were 147 cases of HPV-16,31 cases of HPV-18,83 cases of HPV-11 and 96 cases of HPV-6 respectively.Conclusions In the east area of Guangdong,HPV infection situation of women was severe,it should be very important to control HPV infection and treat cervical erosion effectively.The gene chip technique is a sensitive and specific method for examining HPV.
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Abstract Papillomaviruses are the causative agents of the common wart. Although the human papillomavirus is strongly associated with certain dysplastic and malignant lesions, its exact role in tumour development remains to be determined. This review examines the role of human papilloma virus as a potential oncogenic agent in human mucosal and non‐mucosal squamous cell carcinoma.
Papillomaviridae
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Sinonasal papilloma is a relatively rare disease. However, it is prevalent enough for every otorhinolaryngologist to encounter it several times throughout one's medical practice. The aim of this study was to identify the presence of Human Papilloma Virus in sinonasal specimens of patients with sinonasal papilloma. A cross sectional analytical study was performed on fresh tissue samples from 36 patients with sinonasal papilloma. Samples were studied by polymerase chain reaction for of Human Papilloma Virus detection. In conclusion, the majority of patients were of Human Papilloma Virus negative and there was no statistically significant difference in presence of squamous cell carcinoma in of Human Papilloma Virus positive and negative patients. Thus, further studies are needed to assess other potential factors that may influence the development of sinonasal papilloma.
Inverted Papilloma
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Objective:In 1980s,Germany virologist——Harald Zur Hausen firstly raise the hypotheses that human papilloma virus(HPV) infection closely related to cervical cancer.Afterwards,lots of evidence proved the causal relationship between persistent HPV infection and cervical cancer,and made a conclusion that HPV infection is the necessary cause of cervical cancer.This discovery is marked as a milestone in cervical cancer prevention,which not only promotes the development of HPV DNA-based cervical cancer screening technology,but also guides the development of HPV prophylactic vaccine for cervical cancer.This review states the latest researches of HPV vaccine.
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HPV vaccines
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Objective:To study the relationship between infection of human papilloma virus and juvenile pharynlaryngeal papilloma. Methods:Polymerase chain reaction (PCR) and dot blot hybridization were used to detect HpV 6、11、16、18、33 DNA in 35 samples of pharynlaryngeal papilloma and 10 samples of .vocol nodule. Results:The positive rate of HPV in pharynlaryngeal laryngeed papilloma was 91.4% (30/35) . The positive rate of HPV 6 and HPV 1 1 were 54.2% (19/35) and 25.7% (9/35). The positive rate of multiple types of HPV 6+11 was 11.4% (4/35).The positive rate of HPV 16、18、33 were not significant. The positive rate of HPV in vocol nodule was not significant .Conclusion:It is suggested that infection with HPV,especially with HPV 6 is closely associated with the development of juvenile pharynlaryngeal larynged papilloma in Wenzhou area. [FK(WB80011。5]
Papillomatosis
Dot blot
Southern blot
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