The role of human papilloma virus in skin cancer – current status
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Abstract Papillomaviruses are the causative agents of the common wart. Although the human papillomavirus is strongly associated with certain dysplastic and malignant lesions, its exact role in tumour development remains to be determined. This review examines the role of human papilloma virus as a potential oncogenic agent in human mucosal and non‐mucosal squamous cell carcinoma.Keywords:
Papillomaviridae
A case of laryngeal squamous papilloma in the early stages of development showed histological features suggestive of virus infection. Five years later positive evidence of HPV-6 infection was obtained at a time when the lesion had developed into a squamous cell carcinoma. It is concluded that this case represents a complete example of the virus to papilloma to carcinoma sequence, and as far as is known, is the first reported case of its kind in the larynx.
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Association (psychology)
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Inverted Papilloma
Complete response
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Human papilloma virus (HPV) and carcinomas of the head and neck Increasing evidence for a causal link between human papilloma virus and carcinomas of the cervix has emerged in recent research. This group of species-specific, epitheliotropic viruses has also been associated with tumours of the head and neck, but the individual reports deal only with relatively small sample numbers. In the present review these reports are considered in relation to the methods employed, and it is concluded that HPV is associated with more than 50% of oral and nasal carcinomas, as well as with carcinomas of the larynx and oesophagus. The clinical relevance and strategies for future work are outlined.
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Squamous papilloma is the most common benign oral epithelial lesion, and it is well known to be associated with human papilloma virus 6 and 11. Here, we report a case of squamous papilloma associated with human papilloma viruses (HPV)-32 in a 4-year-old boy who presented with a verrucous lesion on the lower lip. HPV-32 is often associated with a rare benign condition focal epithelial hyperplasia (FEH). A limited number of lesions and the absence of characteristic histology ruled out FEH in our patient. To the best of our knowledge, the association of oral squamous papilloma with HPV-32 is hitherto unreported.
Papillomaviridae
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RT-PCR-based examination of papilloma samples obtained from patients with relapsing papillomatosis of the larynx showed an incidence rate of human papilloma virus (HPV) amounting to 89%. The viral load level of the studied samples, when measured by concurrent RT-PCR HPV, differed by more than 130 times. It made, in the untreated patient, 1.2 x 10(9) hormonal equivalents/ml, i.e. 13-fold higher versus the patient who received pathogenetic therapy. Thus, the approach in question provides for a possibility to monitor the activity of papilloma viral infection and to evaluate the efficiency of different variations of pathogenetic therapy because the "classic" variant of PCR-detection is not informative in the discussed case.
Papillomatosis
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Abstract Papillomaviruses are the causative agents of the common wart. Although the human papillomavirus is strongly associated with certain dysplastic and malignant lesions, its exact role in tumour development remains to be determined. This review examines the role of human papilloma virus as a potential oncogenic agent in human mucosal and non‐mucosal squamous cell carcinoma.
Papillomaviridae
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Sinonasal papilloma is a relatively rare disease. However, it is prevalent enough for every otorhinolaryngologist to encounter it several times throughout one's medical practice. The aim of this study was to identify the presence of Human Papilloma Virus in sinonasal specimens of patients with sinonasal papilloma. A cross sectional analytical study was performed on fresh tissue samples from 36 patients with sinonasal papilloma. Samples were studied by polymerase chain reaction for of Human Papilloma Virus detection. In conclusion, the majority of patients were of Human Papilloma Virus negative and there was no statistically significant difference in presence of squamous cell carcinoma in of Human Papilloma Virus positive and negative patients. Thus, further studies are needed to assess other potential factors that may influence the development of sinonasal papilloma.
Inverted Papilloma
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Papillomatosis
Recurrent Respiratory Papillomatosis
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Objective:To study the relationship between infection of human papilloma virus and juvenile pharynlaryngeal papilloma. Methods:Polymerase chain reaction (PCR) and dot blot hybridization were used to detect HpV 6、11、16、18、33 DNA in 35 samples of pharynlaryngeal papilloma and 10 samples of .vocol nodule. Results:The positive rate of HPV in pharynlaryngeal laryngeed papilloma was 91.4% (30/35) . The positive rate of HPV 6 and HPV 1 1 were 54.2% (19/35) and 25.7% (9/35). The positive rate of multiple types of HPV 6+11 was 11.4% (4/35).The positive rate of HPV 16、18、33 were not significant. The positive rate of HPV in vocol nodule was not significant .Conclusion:It is suggested that infection with HPV,especially with HPV 6 is closely associated with the development of juvenile pharynlaryngeal larynged papilloma in Wenzhou area. [FK(WB80011。5]
Papillomatosis
Dot blot
Southern blot
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