An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

Alfica Sehgal,Scott Barros,Lacramioara Ivanciu,Brian C. Cooley,June Qin,Tim Racie,Julia Hettinger,Mary Carioto,Yongfeng Jiang,Josh Brodsky,Harsha Prabhala,Xuemei Zhang,Husain Attarwala,Renta Hutabarat,Don Foster,Stuart Milstein,Klaus Charisse,Satya Kuchimanchi,Martin Maier,Lubo Nechev,Pachamuthu Kandasamy,Alexander V. Kelin,Jayaprakash K. Nair,Kallanthottathil G. Rajeev,Muthiah Manoharan,Rachel Meyers,Benny Sorensen,Amy Simon,Yesim Dargaud,Claude Negrier,Rodney M. Camire,Akin Akinc

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

2015

An siRNA targeting antithrombin promotes hemostasis in mouse and nonhuman primate models of hemophilia and could represent a new therapeutic option for this disease.

Keywords:

Immunology
Hemostasis
RNA interference
Antithrombin
Medicine
Dosing
Emicizumab
Antithrombins
Factor IX
Disease

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