INTENSITY-DEPENDENT AUDITORY EVOKED POTENTIAL DEFINES SUBGROUPS OF PATIENTS WITH PTSD: A MULTIMODALITY IMAGING STUDY

Post Traumatic Stress Disorder (PTSD) is a complex and heterogeneous psychiatric disorder. Patients with chronic PTSD present with significant psychiatric co-morbidities. Current treatment guidelines recommend the use of selective seroto-nin reuptake inhibitors in PTSD patients, but only 50-60% of these patients respond favorably. To improve the response rate, understanding the underlying pathophysiology is necessary. Serotonergic transmission has been implicated in PTSD and the intensity-dependent auditory evoked potential (IDAEP) is presumed to reflect central serotonergic activity, there-by providing an opportunity to more precisely characterize PTSD patient populations and possibly predict response to treatment. We studied nineteen patients diagnosed with PTSD, matched for age and medications. Based on the stimulus intensity relationship, the patients were divided into two groups: augmenters and reducers. These groups were further evaluated using resting state quantitative EEG and HMPAO-based SPECT brain perfusion acquired simultaneously. The imaging data were correlated with behavioral measures characterizing symptoms of PTSD and measurements of mood state. The augmenters differed from the reducers in the resting state quantitative EEG and SPECT perfusion measures. The differences were primarily localized to the right hemisphere. There were significant differences in measures of PTSD symptoms, but not in overall measures of depression. Item analysis of depression measures showed a significant differ-ence between the augmenters and the reducers in reported sleep difficulties, which correlated with the reported anxiety measures. Objective separation of patients into subgroups based on the IDAEP contributes to the understanding of PTSD biological substrate and can potentially lead to more effective treatment strategies.