Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2).

Tomoteru Yamasaki,Xiaofei Zhang,Katsushi Kumata,Yiding Zhang,Xiaoyun Deng,Masayuki Fujinaga,Zhen Chen,Wakana Mori,Kuan Hu,Hidekatsu Wakizaka,Akiko Hatori,Lin Xie,Masanao Ogawa,Nobuki Nengaki,Richard Van,Yihan Shao,Douglas J. Sheffler,Nicholas D.P. Cosford,Steven H. Liang,Ming-Rong Zhang

Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2).

2020

Metabotropic glutamate receptor 2 (mGlu2) is a known target for treating several central nervous system (CNS) disorders. To develop a viable positron emission tomography (PET) ligand for mGlu2, we ...

Keywords:

Metabotropic glutamate receptor 2
Chemistry
Central nervous system
Metabotropic glutamate receptor
Positron emission tomography
Ligand
Stereochemistry

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