Nephrotic syndrome with pegylated interferon alfa 2a and ribavirin for a patient with chronic hepatitis C

Interferon therapy for hepatitis C can result in renal complica-tions as interstitial nephritis, minimal change disease andimmune complex glomerulonephritis [1]. We present the caseof a 42-year old man infected with chronic hepatitis C whodeveloped focal and segmental glomerulosclerosis (FSGS)after treatment with pegylated interferon alfa 2a and ribavirin.A 42-year-old man reported with incidental detection ofhepatitis C virus infection (anti-HCV positive) at the time ofdonation. His risk factors included surgery for fracture tibia,bloodtransfusionsandfrequentuseofinjectionspossiblywithreusable needles and syringes for joint pains. His physicalexamination was unremarkable. His baseline laboratoryinvestigationsshowedhemoglobin13g/dL,meancorpuscularvolume (MCV) 87 fl, white blood cell count 4000/cumm,platelet count 3,00,000/mm